Supine blood pressure-A clinically relevant determinant of vascular target organ damage in hypertensive patients
| Autor: | Márcio Galindo Kiuchi, Janis M. Nolde, Vance B. Matthews, Omar Azzam, Anu Joyson, Leslie Marisol Lugo-Gavidia, Dennis Kannenkeril, Markus P. Schlaich, Justine Chan, Revathy Carnagarin, Shaun Frost, Lakshini Y. Herat |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Supine position Ambulatory blood pressure Endocrinology Diabetes and Metabolism pulse wave velocity Renal function Blood Pressure 030204 cardiovascular system & hematology Pulse Wave Analysis 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study kidney function Pulse wave velocity Univariate analysis Original Paper business.industry supine blood pressure Blood Pressure Measurement Blood Pressure Monitoring Ambulatory hypertension‐mediated organ damage nocturnal blood pressure Blood pressure Ambulatory Hypertension Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Journal of Clinical Hypertension |
| ISSN: | 1751-7176 |
| Popis: | Night‐time blood pressure (BP) is an important predictor of cardiovascular outcomes. Its assessment, however, remains challenging due to limited accessibility to ambulatory BP devices in many settings, costs, and other factors. We hypothesized that BP measured in a supine position during daytime may perform similarly to night‐time BP when modeling their association with vascular hypertension‐mediated organ damage (HMOD). Data from 165 hypertensive patients were used who as part of their routine clinic workup had a series of standardized BP measurements including seated attended office, seated and supine unattended office, and ambulatory BP monitoring. HMOD was determined by assessment of kidney function and pulse wave velocity. Correlation analysis was carried out, and univariate and multivariate models were fitted to assess the extent of shared variance between the BP modalities and their individual and shared contribution to HMOD variables. Of all standard non‐24‐hour systolic BP assessments, supine systolic BP shared the highest degree of variance with systolic night‐time BP. In univariate analysis, both systolic supine and night‐time BP were strong determinants of HMOD variables. In multivariate models, supine BP outperformed night‐time BP as the most significant determinant of HMOD. These findings indicate that supine BP may not only be a clinically useful surrogate for night‐time BP when ambulatory BP monitoring is not available, but also highlights the possibility that unattended supine BP may be more closely related to HMOD than other BP measurement modalities, a proposition that requires further investigations in prospective studies. |
| Databáze: | OpenAIRE |
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