Interferons: From Virus Inhibitor to Modulator of Amino Acid and Lipid Metabolism

Autor:	Ernest C. Borden, Gerald I. Byrne, I. Bruce Rosenzweig
Rok vydání:	1987
Předmět:	chemistry.chemical_classification Lipoproteins Intracellular parasite Immunology Tryptophan Lipid metabolism Metabolism Biology Lipid Metabolism Antimicrobial Virus In vitro Amino acid Biochemistry chemistry Virology Viral Interference Humans Interferons Amino Acids
Zdroj:	Journal of Interferon Research. 7:591-596
ISSN:	0197-8357
DOI:	10.1089/jir.1987.7.591
Popis:	Purity of interferons has facilitated definition of pleiotropic biological effects. Alterations that might be suspect with use of impure interferons, such as those occurring in tryptophan and lipoprotein metabolism, have been defined both in vitro and in humans. Reduction in tryptophan contributes to antimicrobial effects for intracellular pathogens and may explain some clinical observations. Decreases in plasma lipoproteins occur rapidly and are of a magnitude similar to cholesterol-lowering drugs used clinically. Alteration in metabolism of amino acids and fats substantially extends the biological effects of a virus-inhibitory protein.
Databáze:	OpenAIRE
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