Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis
| Autor: | Ramkumar Menon, Jerome Lapointe, Piotr Laudanski, Nanbert Zhong, Hanns Helmer, Myrthe J.C.S. Peelen, Marian Kacerovsky, Maria Regina Torloni, Ronald F. Lamont, Jossimara Polettini, Jun Takeda, Angela E. Vinturache, Teresa Cobo |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology MEDLINE macromolecular substances 03 medical and health sciences 0302 clinical medicine Risk indicators Pregnancy Internal medicine medicine Humans Multiplex 030212 general & internal medicine Analysis method 030219 obstetrics & reproductive medicine Biological markers integumentary system business.industry prematurity Obstetrics and Gynecology medicine.disease cytokines multiplex assay Premature birth Pediatrics Perinatology and Child Health Population study Premature Birth Female Technological advance business Biomarkers |
| Zdroj: | Polettini, J, Cobo, T, Kacerovsky, M, Vinturache, A E, Laudanski, P, Peelen, M J C S, Helmer, H, Lamont, R F, Takeda, J, Lapointe, J, Torloni, M R, Zhong, N & Menon, R 2017, ' Biomarkers of spontaneous preterm birth : A systematic review of studies using multiplex analysis ', Journal of Perinatal Medicine, vol. 45, no. 1, pp. 71-84 . https://doi.org/10.1515/jpm-2016-0097 |
| ISSN: | 0300-5577 2016-0097 |
| Popis: | Objective: Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Materials and methods: Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Results: Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1β, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. Conclusion: By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk. |
| Databáze: | OpenAIRE |
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