Nervous system development in cephalopods: How egg yolk-richness modifies the topology of the mediolateral patterning system
| Autor: | Sandra Navet, Auxane Buresi, A. Andouche, Yann Bassaglia, Sébastien Baratte, Laure Bonnaud-Ponticelli |
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| Přispěvatelé: | Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cuttlefish Nervous system food.ingredient Embryo Nonmammalian Sepia Body Patterning Polarity in embryogenesis [SDV]Life Sciences [q-bio] [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Neurogenesis Organogenesis Topology Nervous System 03 medical and health sciences food Yolk medicine Animals Molecular Biology [SDV.BDD]Life Sciences [q-bio]/Development Biology ComputingMilieux_MISCELLANEOUS Ovum biology Neuroectoderm [SDV.BA]Life Sciences [q-bio]/Animal biology Gene Expression Regulation Developmental Cell Biology biology.organism_classification Egg Yolk Cephalopod 030104 developmental biology medicine.anatomical_structure embryonic structures PAX6 Developmental Biology |
| Zdroj: | Developmental Biology Developmental Biology, Elsevier, 2016, 415 (1), pp.143-156. ⟨10.1016/j.ydbio.2016.04.027⟩ |
| ISSN: | 1095-564X 0012-1606 |
| DOI: | 10.1016/j.ydbio.2016.04.027⟩ |
| Popis: | Cephalopods possess the most complex centralized nervous system among molluscs and the molecular determinants of its development have only begun to be explored. To better understand how evolved their brain and body axes, we studied Sepia officinalis embryos and investigated the expression patterns of neural regionalization genes involved in the mediolateral patterning of the neuroectoderm in model species. SoxB1 expression reveals that the embryonic neuroectoderm is made of several distinct territories that constitute a large part of the animal pole disc. Concentric nkx2.1, pax6/gsx, and pax3/7/msx/pax2/5/8 positive domains subdivide this neuroectoderm. Looking from dorsal to ventral sides, the sequence of these expressions is reminiscent of the mediolateral subdivision in model species, which provides good evidence for "mediolateral patterning" conservation in cephalopods. A specific feature of cephalopod development, however, includes an unconventional orientation to this mediolateral sequence: median markers (like nkx2.1) are unexpectedly expressed at the periphery of the cuttlefish embryo and lateral markers (like Pax3/7) are expressed centrally. As the egg is rich with yolk, the lips of the blastopore (that classically organizes the neural midline) remain unclosed at the lateral side of the animal pole until late stages of organogenesis, therefore reversing the whole embryo topology. These findings confirm - by means of molecular tools - the location of both ventral and dorsal poles in cephalopod embryos. |
| Databáze: | OpenAIRE |
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