Functional classification analysis of somatically mutated genes in human breast and colorectal cancers
| Autor: | Christopher Holmes, Aedín C. Culhane, Thomas Chittenden, Razvan Sultana, Jennifer M. Taylor, John Quackenbush, Eleanor A. Howe |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Colorectal cancer
Bioinformatics DNA Mutational Analysis Genomics Breast Neoplasms Biology medicine.disease_cause Article Transforming Growth Factor beta1 Breast cancer medicine Genetics Humans Gene Mutation Cancer Computational Biology medicine.disease Gene Expression Regulation Neoplastic Immunology Human genome Breast disease Colorectal Neoplasms Software Genes Neoplasm |
| Zdroj: | Genomics. 91(6):508-511 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/j.ygeno.2008.03.002 |
| Popis: | A recent study published by Sjoblom and colleagues [T. Sjoblom, S. Jones, L.D. Wood, D.W. Parsons, J. Lin, T.D. Barber, D. Mandelker, R.J. Leary, J. Ptak, N. Silliman, S. Szabo, P. Buckhaults, C. Farrell, P. Meeh, S.D. Markowitz, J. Willis, D. Dawson, J.K. Willson, A.F. Gazdar, J. Hartigan, L. Wu, C. Liu, G. Parmigiani, B.H. Park, K.E. Bachman, N. Papadopoulos, B. Vogelstein, K.W. Kinzler, V.E. Velculescu, The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274.] performed comprehensive sequencing of 13,023 human genes and identified mutations in genes specific to breast and colorectal tumors, providing insight into organ-specific tumor biology. Here we present a systematic analysis of the functional classifications of Sjoblom's “CAN” genes, a subset of these validated mutant genes, that identifies novel organ-specific biological themes and molecular pathways associated with disease-specific etiology. This analysis links four somatically mutated genes associated with diverse oncological types to colorectal and breast cancers through established TGF-β1-regulated interactions, revealing mechanistic differences in these cancers and providing potential diagnostic and therapeutic targets. |
| Databáze: | OpenAIRE |
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