Pacing in hypertrophic obstructive cardiomyopathy: A randomized crossover study
| Autor: | X. Jeanrenaud, E. Meisel, Lars Rydén, William J. McKenna, Lukas Kappenberger, Cecilia Linde, Daniel Gras, L. Guize, Claude Daubert, Nicolas Sadoul, Lidia Chojnowska |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Heart disease business.industry Hypertrophic cardiomyopathy Hemodynamics Physical exercise medicine.disease law.invention Angina Bruce protocol Pharmacotherapy law Internal medicine Cardiology Medicine Artificial cardiac pacemaker Cardiology and Cardiovascular Medicine business |
| Popis: | Background Uncontrolled studies have shown that short atrioventricular delay dual chamber pacing reduces outflow tract obstruction in hypertrophic obstructive cardiomyopathy. Although the exact mechanism of this beneficial effect is unclear, this seems a promising potential new treatment for hypertrophic obstructive cardiomyopathy. Method In order to evaluate the impact of pacing therapy, we performed a randomized multicentre double-blind crossover (pacemaker activated vs non activated) study to investigate modification of echocardiography, exercise tolerance, angina, dyspnoea and quality of life in 83 patients with a mean age of 53 (range 22–87) years with symptoms refractory or intolerant to classical drug treatment. Results After 12 weeks of activated or inactivated pacing, independent of which phase was first, the pressure gradient fell from 59±36 mmHg to 30±25 mmHg ( P |
| Databáze: | OpenAIRE |
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