Transforming growth factor-beta1 in adult human microglia and its stimulated production by interleukin-1
| Autor: | Anna da Cunha, James H. Resau, John R. Cottrell, Frank S. Jannotta, Jane J. Jefferson, Jonathan D. Glass, William R. Tyor |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_treatment Immunology Stimulation Transforming Growth Factor beta Virology medicine Humans RNA Processing Post-Transcriptional Cells Cultured Acquired Immunodeficiency Syndrome Microglia biology Interleukin Brain Cell Biology Human brain Transforming growth factor beta Middle Aged Stimulation Chemical Globus pallidus medicine.anatomical_structure Cytokine nervous system Case-Control Studies biology.protein HIV-1 Female Transforming growth factor Interleukin-1 |
| Zdroj: | Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 17(11) |
| ISSN: | 1079-9907 |
| Popis: | Ameboid microglia express human immunodeficiency virus 1 (HIV-1) more frequently than do ramified microglia. These two microglial subtypes might also differ in the frequency with which they express transforming growth factor-beta1 (TGF-beta1), a cytokine that regulates HIV-1 expression in monocytes. Results described here show that ameboid and ramified microglia express TGF-beta1. In brain tissues from HIV-1-infected individuals as compared with seronegative controls, ameboid rather than ramified microglia more frequently expressed TGF-beta1. Ameboid microglia, isolated and cultured from postmortem adult human brain more frequently expressed TGF-beta1 in presence of interleukin-1(IL-1), a cytokine that is elevated in brains of HIV-1-infected individuals when compared with seronegative controls. The stimulation of TGF-beta1 by IL-1 was dose and time dependent, occurring with ameboid microglia isolated from either frontal cortex or globus pallidus but not midbrain pons. Ameboid microglia are similar to the RCA-1-positive cells that form clusters, called microglial nodules, in the brain of HIV-1-infected individuals. Pathologic conditions, such as disseminated microglial nodules, are associated with HIV-1 encephalitis, direct infection of the brain, and moderate to severe neurologic impairment. TGF-beta1 expression in ameboid microglia may play a role in HIV-1 neuropathogenesis. |
| Databáze: | OpenAIRE |
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