Serum albumin and risks of hospitalization and death: Findings from the Atherosclerosis Risk in Communities study
| Autor: | Colleen M. Shannon, Josef Coresh, Morgan E. Grams, Shoshana H. Ballew, Alex R. Chang, Elizabeth Selvin, Natalie Daya, Linda Zhou, Yingying Sang |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Minnesota Population Serum albumin Rate ratio Article Mississippi Interquartile range Risk Factors Internal medicine medicine North Carolina Humans Prospective Studies Mortality Prospective cohort study education Serum Albumin Aged Proportional Hazards Models Aged 80 and over education.field_of_study biology Maryland business.industry Incidence Hazard ratio Pennsylvania medicine.disease Atherosclerosis Hospitalization Cohort biology.protein Female Independent Living Geriatrics and Gerontology business Kidney disease |
| Zdroj: | J Am Geriatr Soc |
| ISSN: | 1532-5415 |
| Popis: | OBJECTIVES To determine whether lower serum albumin in community-dwelling, older adults is associated with increased risk of hospitalization and death independent of pre-existing disease. DESIGN Prospective cohort study of participants in the fifth visit of the Atherosclerosis Risk in Communities (ARIC) study. Baseline data were collected from 2011 to 2013. Follow-up was available to December 31, 2017. Replication was performed in Geisinger, a health system in rural Pennsylvania. SETTING For ARIC, four US communities: Washington County, Maryland; Forsyth County, North Carolina; Jackson, Mississippi; and suburbs of Minneapolis, Minnesota. PARTICIPANTS A total of 4947 community-dwelling men and women aged 66 to 90 years. EXPOSURE Serum albumin. MAIN OUTCOMES Incident all-cause hospitalization and death. RESULTS Among the 4947 participants, mean age was 75.5 years (SD: 5.12) and mean baseline serum albumin concentration was 4.05 g/dL (SD: 0.30). Over a median follow-up period of 4.42 years (interquartile interval: 4.16-5.05), 553 participants (11.2%) died and 2457 participants (49.7%) were hospitalized at least once. The total number of hospitalizations was 5725. In analyses adjusted for demographics and numerous clinical characteristics, including tobacco use, obesity, frailty, cardiovascular disease, kidney disease, diabetes C-reactive protein (CRP), cognitive status, alcohol use, medication use, respiratory disease, and systolic blood pressure, 1 g/dL lower baseline serum albumin concentration was associated with higher risk of both hospitalization (incidence rate ratio [IRR]: 1.58; 95% confidence interval [CI]: 1.36-1.82; p |
| Databáze: | OpenAIRE |
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