Performance of 18F-FDG PET/CT in the Characterization of Adrenal Masses in Noncancer Patients: A Prospective Study
| Autor: | Damien Huglo, Carole Guerin, Catherine Ansquer, Cendrine Archange, Karine Baumstarck, David Taïeb, Frederic Sebag, Claire Houzard, Anderson Loundou, Pierre Olivier, Antoine Tabarin, Elif Hindié, Eric Mirallié, François Pattou, Jean-Christophe Lifante, Magalie Haissaguerre, Laurent Brunaud |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Endocrinology Diabetes and Metabolism Clinical Biochemistry Adrenal Gland Neoplasms 030209 endocrinology & metabolism Context (language use) Malignancy Sensitivity and Specificity Biochemistry Statistics Nonparametric Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Adrenal masses Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Adrenal Glands Biopsy Image Processing Computer-Assisted medicine Humans Prospective Studies Prospective cohort study Aged medicine.diagnostic_test business.industry Biopsy Needle Biochemistry (medical) Washout Middle Aged medicine.disease Immunohistochemistry ROC Curve Positron emission tomography Area Under Curve 030220 oncology & carcinogenesis Population study Female France Nuclear medicine business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 102:2465-2472 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Few prospective studies have evaluated the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the characterization of adrenal masses.To assess the performance of 18F-FDG PET/CT in the malignancy diagnosis of adrenal masses in noncancer patients.Prospective multicenter study.The study population consisted of 87 patients (87 adrenal masses) referred to endocrine surgeons: 56 with mass diameter ≥40 mm and 31 with a diameter40 mm and of indeterminate nature based on unenhanced and washout CT attenuation densities. Fourteen patients had hypercortisolism. Adrenal masses were characterized by 18F-FDG PET/CT. Histology was the gold standard for the diagnosis of malignancy. In the absence of pathological proof (n = 23), the nature of the lesion was based on the 12-month imaging follow-up.Fifteen adrenal masses were classified as malignant (including 11 adrenocortical carcinomas) and 72 as benign. Compared with benign lesions, malignant lesions were larger in size (P = 0.003), had higher unenhanced densities (P = 0.002), lower relative washout values (P = 0.007), and higher 18F-FDG uptake parameters (P10-3). The optimal threshold value of (Tumor SUVmax:Liver SUVmax) the ratio for malignancy was1.5 with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 86.7%, 86.1%, 56.5%, 96.9%, and 86.2%, respectively.Our results show that 18F-FDG PET/CT complements adrenal washout CT in the evaluation of adrenal masses and should be recommended in the evaluation of large and/or indeterminate adrenal masses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|