Early-life skin microbiota in hospitalized preterm and full-term infants
| Autor: | Patrick C. Seed, Noelle Younge, Debra Brandon, Felix Araujo-Perez |
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| Rok vydání: | 2018 |
| Předmět: |
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Bacterial Male Escherichia 0301 basic medicine Microbiology (medical) medicine.medical_specialty Neonatal intensive care unit Staphylococcus Physiology medicine.disease_cause Microbiology lcsh:Microbial ecology 03 medical and health sciences Neonate 0302 clinical medicine Medical microbiology 030225 pediatrics medicine Humans Microbiome Skin Bacteria biology Streptococcus Microbiota Research Infant Newborn Infant Gestational age biology.organism_classification 3. Good health Postnatal age Cross-Sectional Studies Cutaneous 030104 developmental biology lcsh:QR100-130 Female Infant Premature |
| Zdroj: | Microbiome Microbiome, Vol 6, Iss 1, Pp 1-11 (2018) |
| ISSN: | 2049-2618 |
| DOI: | 10.1186/s40168-018-0486-4 |
| Popis: | Background The infant skin microbiota may serve as a reservoir of bacteria that contribute to neonatal infections and stimulate local and systemic immune development. The objectives of our study were to characterize the skin microbiota of preterm and full-term infants during their birth hospitalization and describe its relationship to the microbiota of other body sites and the hospital environment. Results We conducted a cross-sectional study of 129 infants, including 40 preterm and 89 full-term infants. Samples were collected from five sites: the forehead and posterior auricular scalp (skin upper body); the periumbilical region, inguinal folds, and upper thighs (skin lower body); the oral cavity; the infant’s immediate environment; and stool. Staphylococcus, Streptococcus, Enterococcus, and enteric Gram-negative bacteria including Escherichia and Enterobacter dominated the skin microbiota. The preterm infant microbiota at multiple sites had lower alpha diversity and greater enrichment with Staphylococcus and Escherichia than the microbiota of comparable sites in full-term infants. The community structure was highly variable among individuals but differed significantly by body site, postnatal age, and gestational age. Source tracking indicated that each body site both contributed to and received microbiota from other body sites and the hospital environment. Conclusion The skin microbiota of preterm and full-term infants varied across individuals, by body site, and by the infant’s developmental stage. The skin harbored many organisms that are common pathogens in hospitalized infants. Bacterial source tracking suggests that microbiota are commonly exchanged across body sites and the hospital environment as microbial communities mature in infancy. Electronic supplementary material The online version of this article (10.1186/s40168-018-0486-4) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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