Genetics, diagnosis and management of colorectal cancer (Review)
| Autor: | Daniela Rega, Valeria Costabile, Francesca Duraturo, Paolo Delrio, Ugo Pace, Paola Izzo, Marina De Rosa |
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| Přispěvatelé: | DE ROSA, Marina, Pace, Ugo, Rega, Daniela, Costabile, Valeria, Duraturo, Francesca, Izzo, Paola, Delrio, Paolo |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Colorectal cancer medicine.medical_treatment colorectal cancer Disease Drug resistance Metastasis personalised care genetic heterogeneity conventional laparoscopic surgery Internal medicine robotic surgery medicine Humans molecular signaling pathways hereditary colorectal cancers Neoadjuvant therapy minimally invasive surgery Genetics business.industry Genetic heterogeneity Cancer General Medicine Articles medicine.disease Molecular medicine epithelial-to-mesenchymal transition business Colorectal Neoplasms early diagnosis |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| Popis: | Colorectal cancer (CRC) is the third most common type of cancer worldwide and a leading cause of cancer death. Surgery represents the mainstay of treatment in early cases but often patients are primarily diagnosed in an advanced stage of disease and sometimes also distant metastases are present. Neoadjuvant therapy is therefore needed but drug resistance may influence response and concur to recurrent disease. At molecular level, it is a very heterogeneous group of diseases with about 30% of hereditary or familial cases. During colorectal adenocarcinomas development, epithelial cells from gastrointestinal trait acquire sequential genetic and epigenetic mutations in specific oncogenes and/or tumour suppressor genes, causing CRC onset, progression and metastasis. Molecular characterization of cancer associated mutations gives valuable information about disease prognosis and response to the therapy. Very early diagnosis and personalised care, as well as a better knowledge of molecular basis of its onset and progression, are therefore crucial to obtain a cure of CRC. In this review, we describe updated genetics, current diagnosis and management of CRC pointing out the extreme need for a multidisciplinary approach to achieve the best results in patient outcomes. |
| Databáze: | OpenAIRE |
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