Brain abscess caused by Schizophyllum commune: an emerging basidiomycete pathogen
| Autor: | A A Padhye, J D Rihs, Chester B. Good |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Microbiology (medical) Pathology medicine.medical_specialty Antifungal Agents Brain Abscess Schizophyllum Biology Fatal Outcome Amphotericin B medicine Humans Brain abscess Hyaline Mycosis Lung Lung Diseases Fungal Schizophyllum commune Middle Aged biology.organism_classification medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Mycoses Fluconazole Research Article medicine.drug |
| Zdroj: | Journal of Clinical Microbiology. 34:1628-1632 |
| ISSN: | 1098-660X 0095-1137 |
| Popis: | Despite the worldwide distribution and prevalence of Schizophyllum commune, an emerging basidiomycetous pathogen, human infections occur only rarely. We describe the first well-documented pulmonary infection caused by S. commune which disseminated to the brain of a 58-year-old patient undergoing empiric corticosteroid therapy. Magnetic resonance imaging scans revealed ring-enhancing masses. Histologic examination of biopsy tissue from lungs and brain showed hyaline, septate, branched hyphae with clamp connections. Cultures of the lung tissue grew S. commune, which produced numerous, characteristic flabelliform and medusoid fruiting bodies on Czapek's agar. The isolate was susceptible to amphotericin B (MIC, < 0.03 microgram/ml) and fluconazole (MIC, 8 micrograms/ml). Despite treatment with antifungal and antibacterial agents, the patient developed progressive pulmonary failure and bacterial sepsis and died. |
| Databáze: | OpenAIRE |
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