Embryotoxicity and dose-response relationships of selenium in hamsters
| Autor: | Wai Nang Choy, David P. Hanlon, Calvin C. Willhite, Vergil H. Ferm, Steven A. Book |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Administration Oral Hamster chemistry.chemical_element Growth Selenic Acid Biology Toxicology Selenate Selenium chemistry.chemical_compound Sodium Selenite Pregnancy Weight loss Cricetinae Internal medicine medicine Animals Infusions Parenteral Selenium Compounds Selenomethionine Mesocricetus Reproduction Body Weight Abnormalities Drug-Induced Fetal Body Weight Embryo Mammalian medicine.disease Teratology Endocrinology chemistry Injections Intravenous Toxicity Female medicine.symptom |
| Zdroj: | Reproductive Toxicology. 4:183-190 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/0890-6238(90)90057-3 |
| Popis: | Pregnant hamsters were treated with selenite, selenate, and selenomethionine during the critical stages of embryogenesis. The dosing regimens were oral, intravenous, and osmotic minipump infusion. Malformations, mainly encephaloceles, were noted with oral and intravenous selenite and selenate but were associated with maternal toxicity manifested by inanition and weight loss. Fetal body weights and lengths were reduced in a dose-dependent manner with the inorganic forms. Single oral doses of selenomethionine above 77 μmol/kg induced similar malformations but not when the dose was delivered orally over four days nor by minipump over several days. Fetal body weights and lengths were decreased by selenomethionine in a dose-dependent manner. Maternal toxicity was pronounced with the higher doses of selenomethionine. Assigning a specific teratogenic effect to selenium is confounded by maternal toxicit. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|