Development and Validation of a Model to Predict Regression of Large Size Hepatocellular Adenoma

Autor: Michail Doukas, Thomas M. van Gulik, Robert A. de Man, Anne J. Klompenhouwer, Hester F. Lingsma, Belle V. van Rosmalen, R.B. Takkenberg, Martinus Petrus Daniel Haring, Esmee Venema, Joanne Verheij, Jan N. M. IJzermans, Maaike Alblas, Vincent E de Meijer, Maarten Thomeer
Přispěvatelé: Center for Liver, Digestive and Metabolic Diseases (CLDM), Groningen Institute for Organ Transplantation (GIOT), Surgery, Public Health, Pathology, Radiology & Nuclear Medicine, Gastroenterology & Hepatology, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, Graduate School, Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology
Rok vydání: 2019
Předmět:
Adult
medicine.medical_specialty
Multivariate analysis
Adenoma
FEATURES
Population
Clinical Decision-Making
Urology
Conservative Treatment
Risk Assessment
Adenoma
Liver Cell
Contraceptives
Oral
Hormonal
03 medical and health sciences
0302 clinical medicine
Deprescriptions
Weight Loss
medicine
Humans
Hedgehog Proteins
Hepatocyte Nuclear Factor 1-alpha
Obesity
education
Digestive System Surgical Procedures
beta Catenin
Proportional Hazards Models
Retrospective Studies
Inflammation
education.field_of_study
Hepatology
business.industry
Proportional hazards model
Liver Neoplasms
Gastroenterology
Retrospective cohort study
Hepatocellular adenoma
Middle Aged
Overweight
medicine.disease
Regression
Tumor Burden
MOLECULAR CLASSIFICATION
030220 oncology & carcinogenesis
Multivariate Analysis
RISK-FACTORS
030211 gastroenterology & hepatology
Female
business
Body mass index
Zdroj: AMERICAN JOURNAL OF GASTROENTEROLOGY, 114(8), 1292-1298. LIPPINCOTT WILLIAMS & WILKINS
American Journal of Gastroenterology, 114(8), 1292-1298. Springer Nature
American journal of gastroenterology, 114(8), 1292-1298. Springer Nature
ISSN: 1572-0241
0002-9270
DOI: 10.14309/ajg.0000000000000182
Popis: INTRODUCTION: Surgery is advocated in hepatocellular adenomas (HCA) >5 cm that do not regress to METHODS: Data were derived from a multicenter retrospective cohort of female patients diagnosed with HCA >5 cm at first follow-up. Potential predictors included age, body mass index, and HCA diameter at diagnosis (T0), HCA-subtype (hepatocyte nuclear factor 1α inactivated HCA, inflammatory-HCA, unclassified HCA) and "T0-T1 regression-over-time" (percentage of regression between T0 and first follow-up (T1) divided by weeks between T0 and T1). Cox proportional hazards regression was used to develop a multivariable model with time to regression of HCA < 5 cm as outcome. Probabilities at 1 and 2 years follow-up were calculated.RESULTS: In total, 180 female patients were included. Median HCA diameter at T0 was 82.0 mm and at T1 65.0 mm. Eighty-one patients (45%) reached the clinical endpoint of regression to DISCUSSION: In patients diagnosed with HCA > 5 cm that still exceed 5 cm at first follow-up, regression to
Databáze: OpenAIRE
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