Glucagonoma Masquerading as a Mucinous Cancer of the Ovary: Lessons from Cell Biology
Autor: | Kylie L. Gorringe, Jan Pyman, Matthew Wakefield, Cassandra J. Vandenberg, Orla McNally, Jeanne Tie, Gwo-Yaw Ho, David D.L. Bowtell, Clare L. Scott, Sumitra Ananda |
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Rok vydání: | 2020 |
Předmět: |
Oncology
0303 health sciences medicine.medical_specialty Chemotherapy business.industry Colorectal cancer medicine.medical_treatment InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL Cancer Ovary Disease Glucagonoma medicine.disease 3. Good health 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine medicine Immunohistochemistry business Ovarian cancer GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) 030304 developmental biology |
Popis: | High-grade mucinous ovarian cancer (HGMOC) is often a misnomer as the majority of cases are metastatic disease with a gastro-intestinal origin. The standard platinum-based ovarian cancer (OC) chemotherapy regimens are often ineffective, and there are insufficient data to support the use of colorectal cancer (CRC) chemotherapy regimens due to the rarity of HGMOC. We described a cohort of four consecutive suspected HGMOC cases treated at the Royal Women’s Hospital, Melbourne in 2012. Two cases were treated as primary MOC, whereas the other two were considered to be metastatic CRC based on histopathological and clinical evidence. From the RNAseq analysis, we identified two cases of HGMOC whose gene expression profiles were consistent with mucinous epithelial OC, one case that was treated as metastatic CRC with gene expression profile correlated with CRC and one case with neuroendocrine (NET) gene expression features. Interestingly, glucagon was over-expressed in this tumor that was subsequently confirmed by immunohistochemistry. These findings suggest a rare glucagonoma-like NET appendiceal tumor that had metastasized to the surface of ovary and were unresponsive to CRC chemotherapy regimens. In summary, a carefully curated panel of expression markers and selected functional genomics could provide diagnosis and treatment guidance for patients with possible HGMOC. |
Databáze: | OpenAIRE |
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