Tumor budding index and microvessel density assessment in patients with endometrial cancer: A pilot study

Autor: Norbert Stachowicz, Artur Czekierdowski, Mieczysław Chróściel, Tomasz Kluz, Sylwia Czekierdowska, Grzegorz Gurynowicz, Tomasz Łoziński
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Oncology Letters
ISSN: 1792-1082
1792-1074
Popis: The present study aimed to analyze the association between tumor budding index (TBI) and microvessel density (MVD) and selected clinicopathological features in female patients with endometrial cancer (EC). The present study included 137 patients, of whom 117 had endometrial endometrioid cancer and 3 had non-endometrioid EC (NEEC). Additionally, 8 cases of simple endometrial hyperplasia and 9 cases of atypical endometrial hyperplasia were included in the present study. Patient age, menopausal status, tumor histological type, grade and International Federation of Gynecologists and Obstetricians (FIGO) clinical stage were investigated. Immunohistochemistry was utilized to detect MVD using a CD34 antibody, and a laminin-5γ2 antibody was used for TBI assessment. In nonmalignant endometrial lesions, the TBI was significantly lower than that in patients with EC and NEEC (P=0.002). Significant differences in median TBI (MD-TBI) were also observed between patients with low-grade EC (MD-TBI, 4.5) and high-grade EC (MD-TBI, 16.2; P=0.01). Age, body mass index and tumor FIGO stage were not indicated to be associated with the MD-TBI. Premenopausal patients with EC had lower MD-TBI values than postmenopausal patients (0.3 vs. 11.1; P
Databáze: OpenAIRE
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