Temporal lobe epilepsy lateralization using retrospective cerebral blood volume MRI

Autor: Hannah C. Sigmon, Marla J. Hamberger, Jia Guo, Scott A. Small, Frank A. Provenzano, Xinyang Feng
Rok vydání: 2018
Předmět:
Cognitive Neuroscience
Hippocampus
Hippocampal formation
lcsh:Computer applications to medicine. Medical informatics
Functional Laterality
lcsh:RC346-429
Lateralization of brain function
030218 nuclear medicine & medical imaging
Temporal lobe
White matter
Cortical mapping
03 medical and health sciences
Epilepsy
0302 clinical medicine
medicine
Cerebral Blood Volume
Humans
Radiology
Nuclear Medicine and imaging
Cerebral hemodynamics
lcsh:Neurology. Diseases of the nervous system
Retrospective Studies
Brain Mapping
business.industry
Subiculum
Brain
Regular Article
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Cerebral blood volume
Epilepsy
Temporal Lobe
Neurology
lcsh:R858-859.7
Neurology (clinical)
business
Nuclear medicine
030217 neurology & neurosurgery
MRI
circulatory and respiratory physiology
Zdroj: NeuroImage: Clinical, Vol 19, Iss, Pp 911-917 (2018)
NeuroImage : Clinical
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2018.05.012
Popis: Steady-state cerebral blood volume (CBV) is tightly coupled to regional cerebral metabolism, and CBV imaging is a variant of MRI that has proven useful in mapping brain dysfunction. CBV derived from exogenous contrast-enhanced MRI can generate sub-millimeter functional maps. Higher resolution helps to more accurately interrogate smaller cortical regions, such as functionally distinct regions of the hippocampus. Many MRIs have fortuitously adequate sequences required for CBV mapping. However, these scans vary substantially in acquisition parameters. Here, we determined whether previously acquired contrast-enhanced MRI scans ordered in patients with unilateral temporal lobe epilepsy can be used to generate hippocampal CBV. We used intrinsic reference regions to correct for intensity scaling on a research CBV dataset to identify white matter as a robust marker for scaling correction. Next, we tested the technique on a sample of unilateral focal epilepsy patients using clinical MRI scans. We find evidence suggestive of significant hypometabolism in the ipsilateral-hippocampus of unilateral TLE subjects. We also highlight the subiculum as a potential driver of this effect. This study introduces a technique that allows CBV maps to be generated retrospectively from clinical scans, potentially with broad application for mapping dysfunction throughout the brain.
Highlights • Clinically obtained structural MRI parameters overlap with contrast enhanced CBV MRI. • Intensity differences can be corrected using white matter signal. • CBV in unilateral TLE suggest metabolic but not structural ipsilateral changes. • Subiculum implicated as potential driver of unilateral TLE metabolic deficit. • Functional metrics can be potentially extracted from millions of clinical brain MRIs.
Databáze: OpenAIRE
Externí odkaz: