Response of placental vasculature to high glucose levels in the isolated human placental cotyledon
| Autor: | James A. Thorp, Sharon S Crandell, Peter C. Brath, Scott W. Walsh, Jonathan B. Roth, Sue M. Palmer |
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| Rok vydání: | 1990 |
| Předmět: |
Placental cotyledon
medicine.medical_specialty Placenta Hemodynamics Stimulation Blood Pressure Biology In Vitro Techniques Pregnancy Diabetes mellitus Internal medicine medicine Humans Obstetrics and Gynecology Arteries medicine.disease Stimulation Chemical Perfusion medicine.anatomical_structure Endocrinology Glucose Vascular resistance Gestation Female Vascular Resistance |
| Zdroj: | American journal of obstetrics and gynecology. 163(6 Pt 1) |
| ISSN: | 0002-9378 |
| Popis: | We report the effect of high glucose infusion on vascular resistance in isolated human placental cotyledons perfused with Krebs-Ringer-bicarbonate solution containing 80 mg/dl (4.4 mmol/L), 160 mg/dl (8.8 mmol/L), or 320 mg/dl (17.6 mmol/L) D-glucose (n = 6). Placental vascular resistance remained constant during 25-minute perfusion periods with 80 mg/dl followed by 160 mg/dl glucose solution. Subsequent perfusion with 320 mg/dl glucose produced a significant increase in placental vascular resistance. Placentas were also studied in which the placental cotyledon was sequentially perfused for 25-minute periods with solutions containing glucose at 80 mg/dl followed immediately by 320 mg/dl (n = 5). Placental vascular resistance remained constant throughout perfusion with 80 mg/dl glucose solution but increased significantly after beginning perfusion with 320 mg/dl glucose. We conclude that the increase in placental vascular resistance appears to be a function of the high glucose level rather than the duration of glucose perfusion. |
| Databáze: | OpenAIRE |
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