Reduced voluntary activation and increased intracortical inhibition during leg extensions in severe obstructive sleep apnoea patients
| Autor: | Bernard Wuyam, Jean-Louis Pépin, Mathieu Marillier, Sébastien Baillieul, Renaud Tamisier, Mathieu Gruet, Samuel Verges, Patrick Levy, Thibault Le Roux Mallouf |
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| Přispěvatelé: | Hypoxie et physiopathologies cardiovasculaire et respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire HP2, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Université de Toulon (UTLN), Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA), Laboratoire Motricité Humaine Expertise Sport Santé/Equipe de recherche de Toulon (LAMHESS-Toulon), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), HP2 - Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire, Facultés de médecine et de pharmacie Domaine de la merci-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Grenoble, Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2 ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalo-Universitaire de Grenoble (CHU de Grenoble), CHU Grenoble |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Stimulation Isometric exercise medicine.disease Sleep in non-human animals respiratory tract diseases Obstructive sleep apnea Transcranial magnetic stimulation Femoral nerve Internal medicine medicine Cardiology [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Silent period Continuous positive airway pressure business ComputingMilieux_MISCELLANEOUS |
| Zdroj: | ERS International Congress 2017 abstracts ERS International Congress 2017 abstracts, Sep 2017, Milan, France. ⟨10.1183/1393003.congress-2017.OA3432⟩ |
| DOI: | 10.1183/1393003.congress-2017.OA3432⟩ |
| Popis: | Lower muscle strength and endurance have been reported in severe obstructive sleep apnea syndrome (OSAS) patients. Increased intracortical inhibition previously reported at rest in OSAS suggests central neuromuscular impairments in these patients. This study investigated the neuromuscular mechanisms of exercise-induced fatigue in severe OSAS patients before and after an 8-week continuous positive airway pressure (CPAP) treatment. Twelve OSAS patients (age 59±7 yrs; BMI 27±3 kg·m−2; AHI 46±13 events·h−1) and 11 matched controls were included. Maximal voluntary contraction (MVC), voluntary activation (VA) levels assessed by femoral nerve electrical stimulation (FNES) and transcranial magnetic stimulation (TMS) and intracortical inhibition parameters were measured before and during a fatiguing task (FT: repeated isometric knee extensions) until exhaustion. Time to exhaustion was lower in OSAS patients compared to controls (991±461 vs 1375±583s, p=0.017). MVC (138±49 vs 157±49 N·m, p=0.004), VAFNES (86±10 vs 89±8%, p=0.022) and VATMS (86±16 vs 91±7%, p=0.049) were lower in OSAS patients before and during FT. Cortical silent period duration (quadriceps muscles: 225±54 vs 194±47ms at 35%MVC, p This study demonstrates that severe OSAS patients have reduced knee extensors strength and endurance possibly due to central activation deficit and increased intracortical inhibition. An 8-week CPAP treatment did not reverse these neuromuscular impairments. |
| Databáze: | OpenAIRE |
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