Efficacy and safety of latanoprost in eyes with uveitic glaucoma
| Autor: | Gerasimos Georgopoulos, Nikos N. Markomichelakis, Dimitrios Papakonstantinou, Ioannis Halkiadakis, Agori Kostakou, Sonia Chalkidou |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity genetic structures Gonioscopy Visual Acuity Timolol Glaucoma Thiophenes Tonometry Ocular Cellular and Molecular Neuroscience chemistry.chemical_compound Dorzolamide Recurrence Ophthalmology medicine Humans Latanoprost Antihypertensive Agents Intraocular Pressure Sulfonamides medicine.diagnostic_test business.industry medicine.disease Uveitis Anterior eye diseases Sensory Systems Drug Combinations Treatment Outcome chemistry Prostaglandins F Synthetic Intermediate uveitis Female Ocular Hypertension sense organs medicine.symptom business Uveitis Intermediate Uveitis Follow-Up Studies medicine.drug |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 247:775-780 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-009-1036-3 |
| Popis: | To compare the efficacy and safety of latanoprost against a fixed combination of dorzolamide and timolol in eyes with elevated intraocular pressure (IOP) or glaucoma and anterior or intermediate uveitis.Fifty-eight patients with anterior or intermediate uveitis and elevated IOP or glaucoma presented or followed up in the Ocular Inflammation and Immunology Service of General Hospital of Athens were randomly assigned to receive treatment either with latanoprost (30) or with dorzolamide/timolol (28). The main outcome measures were inflammatory relapses and IOP response to treatment.Ten patients (34%) in the latanoprost group and sixteen patients (57%) in the dorzolamide/timolol group experienced relapses of anterior uveitis (p = 0.93). There was no statistical difference between the two groups in respect of inflammatory relapses (p = 0.21). Twenty-one patients were followed up before starting latanoprost. The number of recurrences of anterior uveitis per patient per year before treatment with latanoprost was 0.82 +/- 1.2. The rate of relapses per patient per year after starting latanoprost was 0.39 +/-0.7 for these patients (p = 0.038). After 1 year of treatment, intraocular pressure was dropped from 27.8 +/- 8.4 mmHg to 18.6 +/- 5.3 mmHg (p0.001) in the latanoprost group and from 28.2 +/-8.1 mmHg to 22.6 +/-10.1 mmHg (p0.001) in the dorzolamide/timolol group. Four patients during treatment with latanoprost and five patients during treatment with dorzolamide/timolol developed macular edema.Latanoprost is safe and equally effective to a fixed combination of dorzolamide and timolol in the treatment of uveitic glaucoma. |
| Databáze: | OpenAIRE |
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