Improving Bioprinted Volumetric Tumor Microenvironments In Vitro
| Autor: | Jun Li, Yu Shrike Zhang, Carolina Parra-Cantu, Zongyi Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Biopsy Cell Culture Techniques 3d model Article 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Tumor Cells Cultured Tumor Microenvironment Animals Humans Tumor microenvironment Tissue Engineering business.industry Bioprinting Cancer medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Printing Three-Dimensional Cancer research Drug Screening Assays Antitumor business |
| Zdroj: | Trends Cancer |
| ISSN: | 2405-8025 |
| Popis: | Despite the great breakthroughs in the past few decades in illuminating the pathological mechanisms of cancer and in developing new anticancer drugs, it remains extremely challenging to cure most cancers. Therefore, it is imperative to develop more sophisticated and more biomimetic preclinical cancer models. 3D models combined with dynamic culture techniques show great potential to accurately emulate the volumetric tumor microenvironment (TME). Here we introduce advances in bioprinting technologies for in vitro cancer modeling and their applications. Finally, we look ahead to the remaining challenges associated with current bioprinting strategies and further requirements for standardization. |
| Databáze: | OpenAIRE |
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