Role of adipose tissue in regulating fetal growth in gestational diabetes mellitus
| Autor: | Nanthini Jayabalan, Polin Haghvirdizadeh, Carlos Salomon, Martha Lappas, Caitlyn Nguyen-Ngo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system diseases Placenta Adipokine Adipose tissue Inflammation Fetal Development 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Fetal growth Humans Medicine 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology medicine.disease Pathophysiology Microvesicles Gestational diabetes Diabetes Gestational 030104 developmental biology medicine.anatomical_structure Endocrinology Adipose Tissue Reproductive Medicine Female medicine.symptom business Developmental Biology |
| Zdroj: | Placenta. 102:39-48 |
| ISSN: | 0143-4004 |
| DOI: | 10.1016/j.placenta.2020.05.006 |
| Popis: | Gestational diabetes mellitus (GDM) is a global health issue with significant short and long-term complications for both mother and baby. There is a strong need to identify an effective therapeutic that can prevent the development of GDM. A better understanding of the pathophysiology of GDM and the relationship between the adipose tissue, the placenta and fetal growth is required. The placenta regulates fetal growth by modulating nutrient transfer of glucose, amino acids and fatty acids. Various factors secreted by the adipose tissue, such as adipokines, adipocytokines and more recently identified extracellular vesicles, can influence inflammation and interact with placental nutrient transport. In this review, the role of the placental nutrient transporters and the adipose-derived factors that can influence their function will be discussed. A better understanding of these factors and their relationship may make a potential target for therapeutic interventions to prevent the development of GDM and its consequences. |
| Databáze: | OpenAIRE |
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