Endothelium-dependent hyperpolarization-mediated vasodilatation compensates nitric oxide-mediated endothelial dysfunction during ischemia in diabetes-induced canine coronary collateral microcirculation in vivo

Autor:	Toyotaka Yada, Hiroyuki Tachibana, Hiroaki Shimokawa
Rok vydání:	2018
Předmět:	0301 basic medicine medicine.medical_specialty Physiology Ischemia Collateral Circulation Vasodilation 030204 cardiovascular system & hematology Anterior Descending Coronary Artery Nitric Oxide Microcirculation 03 medical and health sciences Biological Factors 0302 clinical medicine Dogs Physiology (medical) Internal medicine Coronary Circulation medicine Diabetes Mellitus Animals Endothelial dysfunction Molecular Biology Mesenteric arteries business.industry medicine.disease Coronary arteries 030104 developmental biology medicine.anatomical_structure Coronary occlusion Blood Circulation Cardiology Endothelium Vascular Cardiology and Cardiovascular Medicine business
Zdroj:	Microcirculation (New York, N.Y. : 1994). 25(5)
ISSN:	1549-8719
Popis:	OBJECTIVES It has been previously demonstrated that endothelial caveolin-1 plays crucial roles to produce an endothelium-derived hyperpolarizing factor in mouse mesenteric arteries. We examined whether this mechanism is involved in the endothelium-dependent hyperpolarization-mediated responses to compensate reduced NO-mediated responses in diabetes mellitus during coronary occlusion in dogs in vivo. METHODS Canine subepicardial collateral coronary small arteries (≥100 μm) and arterioles (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6d5e809dd480fb5ee3207a68c78abb https://pubmed.ncbi.nlm.nih.gov/29665152 Zobrazit plný text záznamu Plný text