Nuclear but not mitochondrial‐encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease
| Autor: | Gary Olsen, Jennifer Nolz, Carl W. Cotman, Paul D. Coleman, Sidney M. Hecht, Nicole C. Berchtold, Diego Mastroeni, Omar M. Khdour, Elaine Delvaux |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Aging Mitochondrial DNA medicine.medical_specialty Pathology Microarray Epidemiology Hippocampus Oxidative phosphorylation Mitochondrion Biology Oxidative Phosphorylation Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Alzheimer Disease Internal medicine medicine Humans Gene Oligonucleotide Array Sequence Analysis Aged 80 and over Microarray analysis techniques Health Policy Mitochondria Nuclear DNA Psychiatry and Mental health 030104 developmental biology Endocrinology Female Autopsy Neurology (clinical) Geriatrics and Gerontology Cognition Disorders 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia. 13:510-519 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2016.09.003 |
| Popis: | Introduction We have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative phosphorylation (OXPHOS) complexes (I–V) in the hippocampus from young controls, age matched, mild cognitively impaired (MCI), and Alzheimer's disease (AD) subjects. Methods Hippocampal tissues from 44 non-AD controls (NC), 10 amnestic MCI, and 18 AD cases were analyzed on Affymetrix Hg-U133 plus 2.0 arrays. Results The microarray data revealed significant down regulation in OXPHOS genes in AD, particularly those encoded in the nucleus. In contrast, there was up regulation of the same gene(s) in MCI subjects compared to AD and ND cases. No significant differences were observed in mtDNA genes identified in the array between AD, ND, and MCI subjects except one mt-ND6 . Discussion Our findings suggest that restoration of the expression of nuclear-encoded OXPHOS genes in aging could be a viable strategy for blunting AD progression. |
| Databáze: | OpenAIRE |
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