Decorated CuO nanoparticles over chitosan-functionalized magnetic nanoparticles: Investigation of its anti-colon carcinoma and anti-gastric cancer effects
| Autor: | Ayman El-Meghawry El-Kenawy, Yuping Wang, Liangjun Xue, Attalla F. El-kott |
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| Rok vydání: | 2021 |
| Předmět: |
General Chemical Engineering
Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences Chitosan chemistry.chemical_compound medicine Viability assay Copper oxide QD1-999 Nanocomposite Cancer General Chemistry 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Cuo nanoparticles Magnetic nanocomposite Colorectal carcinoma Chemistry chemistry Cell culture Magnetic nanoparticles Gastric cancer 0210 nano-technology Nuclear chemistry |
| Zdroj: | Arabian Journal of Chemistry, Vol 14, Iss 7, Pp 103201-(2021) |
| ISSN: | 1878-5352 |
| DOI: | 10.1016/j.arabjc.2021.103201 |
| Popis: | In this study, a green protocol for supporting CuO nanoparticles over chitosan-modified amino-magnetic nanoparticles is described. The physicochemical and morphological properties of the desired nanocomposite assessed by various techniques like ICP, FT-IR, FE-SEM, EDX, TEM, XRD and VSM. In the oncological part of the recent study, the Cu(NO3)2, Fe3O4, and Fe3O4-NH2@CS/CuO nanocomposite cell viability was very low against human gastric cancer cell lines i.e. MKN45, AGS, and KATO III and human colorectal carcinoma cell lines i.e. HT-29, HCT 116, HCT-8 [HRT-18], and Ramos.2G6.4C10. The IC50 of Fe3O4-NH2@CS/CuO nanocomposite against MKN45, AGS, KATO III, HT-29, HCT 116, HCT-8 [HRT-18], and Ramos.2G6.4C10 cell lines were 517, 525, 544, 282, 214, 420, and 477 µg/mL, respectively. Thereby, the best anti-gastro-duodenal cancers findings of our Fe3O4-NH2@CS/CuO nanocomposite was seen in the HCT 116 cell line case. |
| Databáze: | OpenAIRE |
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