Contribution of structural biology to clinically validated target proteins
| Autor: | Shigeyuki Yokoyama, Akiko Tanaka, Naoko Ogawa, Sanae Dodo, Kunihiro Tanikawa, Sotaro Shibayama, Masumi Mori |
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| Rok vydání: | 2008 |
| Předmět: |
Pharmacology
Glycosylation Protein Conformation Druggability Protein Data Bank (RCSB PDB) Proteins Computational biology computer.file_format Bioinformatics Protein Data Bank Transmembrane protein chemistry.chemical_compound Drug Delivery Systems chemistry Structural biology Drug Design Drug Discovery Humans Databases Protein computer |
| Zdroj: | Drug Discovery Today. 13:469-472 |
| ISSN: | 1359-6446 |
| DOI: | 10.1016/j.drudis.2008.03.008 |
| Popis: | We identified six groups of diseases expected to cause serious future health issues on the basis of a WHO report. Approved drugs for these diseases were associated with 409 target proteins; however, the percentage of selected proteins with full-length structural information deposited in the Protein Data Bank (PDB) was only 9.8%. The reason for the low percentage may be as a result of a disproportionate number of intractable proteins with multiple transmembrane regions and variable, or undefined glycosylation patterns, which impede protein preparation and crystallization, in such druggable proteins. We stress the importance of structural analysis of proteins, especially approved-drug target proteins, and the development of new methods to enable structural analyses of presently intractable proteins. In addition, we present an overview of large structural biology projects. |
| Databáze: | OpenAIRE |
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