Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma
| Autor: | Jean-Louis Guéant, Agnès Leroux, Béatrice Marie, Jean-Michel Vignaud, Claire Charra-Brunaud, M. Agopiantz, Hélène Busby-Venner, Guillaume Gauchotte, Olivier Morel, Shyue-Fang Battaglia-Hsu, Judicaël Hotton |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Disease-Free Survival Pathology and Forensic Medicine Cohort Studies 03 medical and health sciences 0302 clinical medicine Minichromosome maintenance Internal medicine Biomarkers Tumor medicine Carcinoma Humans Molecular Biology Aged Retrospective Studies biology business.industry MCM6 Endometrial cancer Cell Biology General Medicine Middle Aged Cell cycle Prognosis medicine.disease Minichromosome Maintenance Complex Component 6 Endometrial Neoplasms 030104 developmental biology 030220 oncology & carcinogenesis Ki-67 Cohort biology.protein Immunohistochemistry Female business Carcinoma Endometrioid |
| Zdroj: | Virchows Archiv. 472:623-633 |
| ISSN: | 1432-2307 0945-6317 |
| Popis: | Minichromosome maintenance complex component 6 (MCM6) is involved in initiating DNA replication and is upregulated during licensed G0 phase of the cell cycle. This early expression permits its labeling of more proliferating cells than those by Ki-67. Here using a cohort of 89 endometrioid adenocarcinoma, we report findings made on the prognostic value of MCM6 based on immunohistochemical labeling index (LI) of the protein in comparison with that of Ki67 as no such information is currently available. Additionally, we examined the prognostic values of these markers based on their mRNA expression using a cohort of uterine corpus endometrial carcinoma (UCEC, n = 307) taken from The Cancer Genome Atlas (TCGA) database. Our evidence indicated the presence of a positive correlation between the LI of MCM6 and the histological grade of endometrioid endometrial adenocarcinoma (grade I, 66.7%; grade II, 75.3%; grade III, 81.4%; p |
| Databáze: | OpenAIRE |
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