Correlation between adverse events after drug treatment and the MDR1 C3435T polymorphism in advanced non-small cell lung cancer patients in an Asian population: a meta-analysis
| Autor: | Hua Luo, Guangmei Qin, Caoyuan Yao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Lung Neoplasms Drug-Related Side Effects and Adverse Reactions Genotype Meta-Analysis and Systematic Review adverse event MDR1 C3435T polymorphism Antineoplastic Agents Polymorphism Single Nucleotide Biochemistry Correlation 03 medical and health sciences Drug treatment 0302 clinical medicine Asian People Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans Genetic Predisposition to Disease Adverse effect Lung cancer non-small cell lung cancer C3435t polymorphism business.industry Biochemistry (medical) Asian population Cell Biology General Medicine medicine.disease meta-analysis 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Non small cell business |
| Zdroj: | The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/0300060519858012 |
| Popis: | Objective To determine the association between the multidrug resistance 1 gene ( MDR1) C3435T polymorphism and adverse drug reactions in advanced non-small cell lung cancer (NSCLC) patients in Asia. Methods Literature about the relationship between the MDR1 C3435T polymorphism and adverse drug reactions in advanced NSCLC patients were collected from three English language databases (PubMed, Cochrane, and Embase) as well as three Chinese databases (Wanfang, China Knowledge Network, and the Chinese Biomedical Literature Database), and summarized by a meta-analysis. Results NSCLC patients with the T allele or TT genotype were significantly more likely to experience diarrhea than those with other genotypes under the allele model (odds ratio [OR] = 1.64, 95% confidence interval [CI]: 1.04–2.61), homozygous model (OR = 3.87, 95% CI: 1.49–10.07), and recessive model (OR = 4.48, 95% CI: 1.88–10.68). Similarly, these patients were significantly more likely to experience skin rash under the allele model (OR = 2.41, 95% CI: 1.24–4.66), homozygous model (OR = 4.77, 95% CI: 1.13–20.15), and dominant model (OR = 1.77, 95% CI: 1.03–3.05). Conclusions Asian NSCLC patients with the MDR1 C3435T T allele or TT genotype are significantly more likely to develop diarrhea and rash after drug treatment. |
| Databáze: | OpenAIRE |
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