Hemoglobin A1c and C-reactive protein are independently associated with blunted nocturnal blood pressure dipping in obesity-related prediabetes
| Autor: | William G. Haynes, Christopher J Wagner, Graziela Z. Kalil, Gary L. Pierce, Jess G. Fiedorowicz, Amy L. Sindler, Tiwaloluwa Ajibewa, Abbi D. Lane-Cordova |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Ambulatory blood pressure Physiology Blood Pressure 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Article Body Mass Index Prediabetic State 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine medicine Humans Obesity Prediabetes Pulse wave velocity Aged Glycemic Glycated Hemoglobin biology business.industry C-reactive protein Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Circadian Rhythm C-Reactive Protein Cross-Sectional Studies Blood pressure Endocrinology biology.protein Female Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Hypertension Research. 41:33-38 |
| ISSN: | 1348-4214 0916-9636 |
| Popis: | Blunted nocturnal dipping in blood pressure (BP) is associated with increased cardiovascular disease (CVD) risk in middle-aged/older adults. The prevalence of blunted nocturnal BP dipping is higher in persons with obesity and diabetes, conditions that are also associated with elevated aortic stiffness and inflammation. Therefore, we hypothesized that elevated glycemia, inflammation and aortic stiffness would be inversely associated with the magnitude of nocturnal systolic BP dipping among middle-aged/older adults with obesity at high CVD risk. Twenty-four hour ambulatory BP monitoring, aortic stiffness (carotid-femoral pulse wave velocity, CF-PWV), hemoglobin A1c (HbA1c) and inflammation (C-reactive protein, CRP) were measured in 86 middle-aged/older adults with obesity and at least one other CVD risk factor (age 40-74 years; 34 male/52 female; body mass index=36.7±0.5 kg m-2; HbA1c=5.7±0.04%). In the entire cohort, CRP (β=0.40±0.20, P=0.04), but not HbA1c or CF-PWV was independently associated with systolic BP dipping percent (Model R2=0.07, P=0.12). In stratified (that is, presence or absence of prediabetes) multiple linear regression analysis, HbA1c (β=6.24±2.6, P=0.02) and CRP (β=0.57±0.2, P=0.01), but not CF-PWV (β=0.14± 2.6, P=0.74), were independently associated with systolic BP dipping percent (Model R2=0.32, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink