Encapsulated papillary carcinoma of the thyroid gland: Clincopathological and cytoflurometric study in comparison with non-encapsulated papillary carcinomy
| Autor: | Shinji Sakurai, Tsunehiro Ishida, Tetsunari Oyama, Takashi Nakajima, Atsuhiko Sakamoto, Takashi Joshita, Kaoru Ishii |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Tumor cells Pathology and Forensic Medicine Carcinoma Humans Medicine Fluorometry Thyroid Neoplasms Aged Tumor size business.industry Thyroid DNA Neoplasm General Medicine Middle Aged medicine.disease Carcinoma Papillary Nuclear DNA medicine.anatomical_structure embryonic structures cardiovascular system Encapsulated papillary carcinoma Female Papillary carcinoma business circulatory and respiratory physiology |
| Zdroj: | Pathology International. 43:516-521 |
| ISSN: | 1440-1827 1320-5463 |
| DOI: | 10.1111/j.1440-1827.1993.tb01165.x |
| Popis: | Clinicopathological and cytofluorometric studies were performed on nine encapsulated (EPC) and 23 non-encapsulated (non-EPC) carcinomas of the thyroid gland. The average age of the patients with EPC was 33 years, which was significantly younger than that of those with non-EPC. The average tumor size of EPC was twice as large as that of intraglandular non-encapsulated carcinoma. All patients with EPC were alive without disease, but three out of 23 patients with non-EPC had a recurrence of the disease or died. Cytofluorometric studies showed that the mean nuclear DNA content and percentage of tumor cells in the S-G2M phase of EPC were lower than that of non-EPC. According to the DNA histogram pattern, all EPC showed distinct modal DNA values in the diploid or near diploid region of normal cells. However non-EPC, especially extra-glandular non-encapsulated papillary carcinoma, showed a wide variety of DNA histogram patterns. The present study suggested that EPC is a distinct subtype of papillary carcinoma of the thyroid gland clinicopathologically and that cytofluorometrically it is different from non-EPC. |
| Databáze: | OpenAIRE |
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