Recyclable supported Pd-NHC catalytic systems for the copper free Sonogashira cross-coupling in flow

Autor: Penafiel, Itziar, Martinez-Lombardia, A, Godard, C, Claver, Carmen, Lapkin, AA
Přispěvatelé: Lapkin, Alexei [0000-0001-7621-0889], Apollo - University of Cambridge Repository
Rok vydání: 2019
Předmět:
DOI: 10.17863/cam.35134
Popis: A new family of well-defined NHC-Pd complexes immobilised onto silica, alumina and titania is reported. The catalysts display activity and recyclability in the Sonogashira cross-coupling reactions under batch and continuous flow conditions. Under batch conditions the new catalytic systems were recycled up to four times with yields over 80%. These catalysts have a broad substrate scope of different aryl bromides and alkynes. The titania-supported catalysts show good conversions under continuous flow conditions at least over 8 hours on stream using MeOH as solvent.
Databáze: OpenAIRE