Temporal Relationship between Depressive Symptoms and Cognitive Impairment: The Italian Longitudinal Study on Aging
| Autor: | Emanuele Scafato, Alessia D'Introno, Francesco Panza, Gianluigi Vendemiale, Angelo Del Parigi, Cristiano Capurso, Claudia Gandin, Vincenzo Solfrizzi, Vincenza Frisardi, Richard J. Caselli, Anna M. Colacicco, Roberta Chiloiro, Antonio Capurso, Pierluigi Scapicchio |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Aging Longitudinal study medicine.medical_specialty Time Factors Population Cognition Alzheimer Disease medicine Humans Dementia Longitudinal Studies Cognitive decline Vascular dementia Psychiatry education Episodic memory Aged Aged 80 and over education.field_of_study Depression Dementia Vascular General Neuroscience General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology Italy Mental Recall Regression Analysis Female Geriatrics and Gerontology Alzheimer's disease Cognition Disorders Psychology Follow-Up Studies Clinical psychology |
| Zdroj: | Journal of Alzheimer's Disease. 17:899-911 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-2009-1111 |
| Popis: | The temporal relationship between depression and cognitive decline has not been extensively investigated in prospective population-based studies, and most of these have only looked in one direction. We estimated the bidirectional temporal relationship between depressive symptoms and cognitive function in older subjects, excluding subjects with a clinical diagnosis of dementia or mild cognitive impairment (MCI). In a total of 2,963 individuals from the Italian Longitudinal Study on Aging, depressive symptoms, global cognitive function, and episodic memory were measured. Dementia, Alzheimer's disease, vascular dementia, and MCI were classified using current clinical criteria. Depressive symptoms at baseline were associated with an accelerated global cognitive function decline and an accelerated rate of episodic memory delayed recall decline in a 3.5-year follow-up. Finally, an accelerated increase with time of depressive symptoms during the same follow-up period was not associated with global cognitive function and episodic memory (immediate and delayed recall). In older subjects non-cognitively impaired, depressive symptoms at baseline predicted change over time of global cognitive decline and episodic memory delayed recall. Global cognitive function and episodic memory at baseline were not associated with the course of depressive symptoms during the follow-up. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|