Metallothionein expression in carcinoma of the gallbladder
| Autor: | Vijay K. Shukla, Manoj Pandey, A Pitale, N C Aryya, Vinod Kumar Dixit, A. Gautam, C D Reddy |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Histology Biology medicine.disease_cause Gastroenterology Pathology and Forensic Medicine Internal medicine Cholecystitis Carcinoma medicine Humans Metallothionein Gallbladder cancer Carcinogen Aged Gallbladder General Medicine Middle Aged medicine.disease Immunohistochemistry medicine.anatomical_structure Female Gallbladder Neoplasms Carcinogenesis |
| Zdroj: | Histopathology. 33:154-157 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1046/j.1365-2559.1998.00474.x |
| Popis: | Aims Metallothioneins (MT) are sulphur-rich, low molecular-weight, intracellular metal-binding proteins with a possible role in carcinogenesis of some human tumours. Metallothionein expression in gallbladder cancer has not been studied previously. Methods and results Immunohistochemical expression of metallothionein was studied in 42 gallbladders (27 cases of carcinoma of the gallbladder, eight chronic cholecystitis and seven cases of normal gallbladder). Metallothionein expression was significantly higher in cases with carcinoma of the gallbladder (70.37%) as compared to chronic cholecystitis (25%) and normal gallbladders (0%). There was a trend suggestive of increasing MT expression with increasing histological dedifferentiation of carcinoma of the gallbladder. Conclusions The increased expression of MT in cases of carcinoma of the gallbladder may represent an increased exposure to heavy metals, which are known carcinogens, and may have a role in gallbladder carcinogenesis. Metallothionein over-expression in carcinoma of the gallbladder may be relevant to the poor prognosis and chemoresistance seen in these cases. |
| Databáze: | OpenAIRE |
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