Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae)
| Autor: | Emmanoel V. Costa, Luis Henrique Gonzaga Ribeiro, Valéria Regina de Souza Moraes, Andersson Barison, Fernanda Ramos Gadelha, Antonio G. Ferreira, Dayanne Meneses Silva, Sócrates Cabral de Holanda Cavalcanti, Paulo Cesar de Lima Nogueira, Marcos José Salvador |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Stigmasterol
Traditional medicine Candida glabrata Campesterol Xylopia laevigata General Chemistry Aedes aegypti Biology biology.organism_classification ent-kaurane-diterpenes lcsh:Chemistry chemistry.chemical_compound larvicidal and antifungal properties lcsh:QD1-999 Phytochemical chemistry Annonaceae Botany Candida dubliniensis Xylopia |
| Zdroj: | Química Nova v.35 n.8 2012 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ ResearcherID Química Nova, Vol 35, Iss 8, Pp 1570-1576 (2012) Química Nova, Volume: 35, Issue: 8, Pages: 1570-1576, Published: 2012 |
| Popis: | Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic acid, and ent-16β,17-dihydroxy-kauran-19-oic acid, as well as spathulenol and a mixture of β-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 µg mL-1 was found for ent-3β-hydroxy-kaur-16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 µg mL-1. |
| Databáze: | OpenAIRE |
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