WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience
| Autor: | Hans Carl Hasselbalch, Karsten Nielsen, Helle Charlotte Knudsen, Ann Brinch Madelung, Preben Løvgreen, Jürgen Thiele, Anne Falensteen, Henrik Bondo, Kira Dynnes Svendsen, Elisabeth Ralfkiaer, Signe Ledou Nielsen, Theis Lange, Inger Stamp |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Microbiology (medical) Pathology medicine.medical_specialty Biopsy education Fleiss' kappa World Health Organization Pathology and Forensic Medicine Danish Young Adult Bone Marrow Internal medicine Humans Immunology and Allergy Medicine Myeloproliferative Disorders business.industry General Medicine Subtyping language.human_language Case-Control Studies Clinical diagnosis language Bone Marrow Neoplasms business Who classification |
| Zdroj: | APMIS. 123:787-792 |
| ISSN: | 0903-4641 |
| Popis: | We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p = 0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis. |
| Databáze: | OpenAIRE |
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