Autologous fat grafting for nerve regeneration and neuropathic pain: current state from bench-to-bedside
| Autor: | Theodore A. Kung, Paul S. Cederna, Stephen Wp Kemp, Jarred V. Bratley, Amir Dehdashtian, Shelby R Svientek, Tariq M Awan |
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| Rok vydání: | 2020 |
| Předmět: |
Embryology
Biomedical Engineering Adipose tissue Bioinformatics 03 medical and health sciences 0302 clinical medicine Peripheral Nerve Injuries Humans Medicine Autologous fat grafting Peripheral Nerves 030304 developmental biology 0303 health sciences business.industry Regeneration (biology) Bench to bedside Nerve Regeneration Allodynia Adipose Tissue Neuropathic pain Peripheral nerve injury Neuralgia Stem cell medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Regenerative Medicine. 15:2209-2228 |
| ISSN: | 1746-076X 1746-0751 |
| Popis: | Despite recent advances in microsurgical techniques, functional recovery following peripheral nerve injury remains slow and inadequate. Poor peripheral nerve regeneration not only leaves patients with significant impairments, but also commonly leads to the development of debilitating neuropathic pain. Recent research has demonstrated the potential therapeutic benefits of adipose-derived stem cells, to enhance nerve regeneration. However, clinical translation remains limited due to the current regulatory burdens of the US FDA. A reliable and immediately translatable alternative is autologous fat grafting, where native adipose-derived stem cells present in the transferred tissue can potentially act upon regenerating axons. This review presents the scope of adipose tissue-based therapies to enhance outcomes following peripheral nerve injury, specifically focusing on their role in regeneration and ameliorating neuropathic pain. |
| Databáze: | OpenAIRE |
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