Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study
Autor: | Sara Muller, Alyshah Abdul Sultan, Richard Partington, Christian D Mallen, Toby Helliwell |
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Rok vydání: | 2020 |
Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty education Polymyalgia rheumatica Cohort Studies symbols.namesake RC925 Rheumatology Internal medicine medicine Humans Poisson regression Cause of death Aged Retrospective Studies business.industry Medical record Mortality rate Retrospective cohort study Middle Aged medicine.disease R1 Confidence interval United Kingdom Polymyalgia Rheumatica symbols Female business Body mass index RC |
Zdroj: | Arthritis careresearchREFERENCES. 73(12) |
ISSN: | 2151-4658 2151-464X |
Popis: | Objective To determine whether a diagnosis of polymyalgia rheumatica (PMR) is associated with premature mortality. Methods We extracted anonymised electronic medical records of patients over the age of 40 years, who were eligible for linkage with the Office for National Statistics (ONS) Death Registration dataset, from the Clinical Practice Research Datalink from 1990-2016. Patients with PMR were individually matched by age, sex and registered General Practice with up to 5 controls without PMR. The total number and proportion of deaths and mortality rates were calculated. The mortality rate ratio (MRR), with 95% confidence interval (CI), adjusted for age, sex, region, smoking status, body mass index (BMI), and alcohol consumption, was calculated using Poisson regression. The twenty most common causes of death were tabulated. Results 18,943 patients with PMR were matched to 87,801 controls. Mean (standard deviation) follow-up after date of diagnosis was 8.0 (4.4) years in patients with PMR, and 7.9 (4.6) in controls. PMR was not associated with an increase in the risk of death (adjusted MRR 1.00 [95% CI 0.97, 1.03]) compared to matched controls. Causes of death were broadly similar between patients with PMR and controls, although patients with PMR were slightly more likely to have a vascular cause of death recorded (24% vs 23%). Conclusions A diagnosis with PMR does not appear to increase the risk of premature death. Minor variations in cause of death were observed, but overall this study is reassuring for patients with PMR and clinicians. |
Databáze: | OpenAIRE |
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