Analysis of Threshold Effect of Urinary Heavy Metal Elements on the High Prevalence of Nephrolithiasis in Men
| Autor: | Qianyuan Yang, Yalan Liu, Feng Hong, Zixiu Qin, Qiaorong Wang, Xuejie Tang, Juan Lei, Cailiang Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Male
China Threshold limit value Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry chemistry.chemical_element Physiology Environmental pollution Urine Nephrolithiasis Biochemistry Risk Assessment Arsenic Inorganic Chemistry Metal Metals Heavy Prevalence Medicine Humans Cadmium business.industry Biochemistry (medical) General Medicine Mercury Mercury (element) chemistry visual_art visual_art.visual_art_medium business Environmental Monitoring |
| Zdroj: | Biological trace element research. 200(3) |
| ISSN: | 1559-0720 |
| Popis: | Exposure to heavy metals in the environment exerts serious effects on kidney health. However, the effects of joint exposure on the kidneys have been rarely studied, particularly in non-occupational exposure high-risk populations. This study provided a reference threshold range of heavy metals in urine and explored the effect of joint exposure on nephrolithiasis in men. The data were obtained from the China Multi-Ethnic Cohort database, and 1502 men were included in the study. A two-piece-wise regression model was used to assess the dose–response relationship between heavy metal exposure and nephrolithiasis. The least absolute shrinkage and selection operator regression model was used to calculate the score of joint exposure to heavy metals. The threshold effect analysis revealed a linear relationship between the concentration of arsenic (As) in the urine and the prevalence of nephrolithiasis, whereas a nonlinear relationship was observed with cadmium (Cd), chromium (Cr), mercury (Hg), and lead (Pb). In addition, As, Cd, Cr, Hg, and Pb may significantly affect the joint exposure effect. Moreover, the final risk of nephrolithiasis increased by 123% (P for trend |
| Databáze: | OpenAIRE |
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