Study of SMAD-Dependent Signal Pathway in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H1N1 Virus
| Autor: | A. V. Kovner, L. A. Cherdantseva, E. V. Shatskaya, V. A. Shkurupy, Alexander Shestopalov, O. V. Potapova |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Pulmonary Fibrosis Smad Proteins SMAD medicine.disease_cause General Biochemistry Genetics and Molecular Biology Virus Mice 03 medical and health sciences Influenza A Virus H1N1 Subtype 0302 clinical medicine Fibrosis Influenza Human Pulmonary fibrosis Animals Outbred Strains Influenza A virus medicine Animals Humans Fibroblast Lung business.industry General Medicine medicine.disease 030104 developmental biology medicine.anatomical_structure Immunology Signal transduction business 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 162:647-649 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-017-3678-1 |
| Popis: | Early fibrosis of the visceral organs is one of the main complications of infection caused by influenza A virus. Structural manifestations and molecular regulators of the epithelialmesenchymal transformation as a possible mechanism of fibrosis progression were studied in mice infected with influenza A/H1N1 A/Tomsk/13/2010 virus. We found early fibrosis of the lungs against the background of minor changes in fibroblast count. However, enhanced expression of TGF-β and SMAD-2 by macrophages and alveolocytes attested to possible development of epithelial-mesenchymal transformation and its contribution to activation of fibrogenesis process in the lungs. |
| Databáze: | OpenAIRE |
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