A genetic variant in IL-15R α correlates with physical activity among European-American adults
| Autor: | Eric Selinsky, Niall M. Moyna, Linda S. Pescatello, Heather Gordish-Dressman, Paul S. Visich, Robert F. Zoeller, Eric P. Hoffman, Michael Bruneau, Garrett I. Ash, Paul D. Thompson, Joseph M. Devaney, Sean Walsh, Paul M. Gordon, Theodore J. Angelopoulos, Priscilla M. Clarkson |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Genotype Physical activity Polymorphism Single Nucleotide White People Body Mass Index 03 medical and health sciences 0302 clinical medicine Gene Frequency Interleukin-15 Receptor alpha Subunit Polymorphism (computer science) Internal medicine Myokine cytokine Genetics medicine Humans Muscle Strength Muscle Skeletal 10. No inequality Molecular Biology Alleles Genetics (clinical) Interleukin-15 2. Zero hunger exercise business.industry Genetic variants Genetic Variation Original Articles 030229 sport sciences United States Protein catabolism Light intensity Phenotype 030104 developmental biology Endocrinology Body Composition Female Original Article polymorphisms business Body mass index |
| Zdroj: | Molecular Genetics & Genomic Medicine |
| ISSN: | 2324-9269 |
| DOI: | 10.1002/mgg3.368 |
| Popis: | Background Interleukin‐15 (IL‐15) is a myokine associated with muscle strength, possibly by attenuating protein breakdown. A variant in the alpha‐receptor (IL‐15Rα 1775 A>C, rs2228059) partially modulates the muscle strength and size response to resistance training. We examined if this polymorphism associated with habitual physical activity among European‐American adults. Methods Men (n = 240, 23.7 ± 0.3 year, body mass index [BMI] 25.3 ± 0.3 kg/m2) and women (n = 292, 23.2 ± 0.3 year, 24.0 ± 0.3 kg/m2) were genotyped. Physical activity phenotypes were derived from the Paffenbarger Physical Activity Questionnaire. Analysis of covariance (ancova) tested log‐transformed differences between the IL‐15Rα genotype and physical activity phenotypes by gender with age and BMI as covariates. Results Men with the IL‐15Rα 1775AA genotype spent more time in light intensity physical activity (39.4 ± 2.4 hr/week) than men with the CC genotype (28.6 ± 2.3 hr/week, (p = .009). Conclusion Further research is needed to confirm our finding and determine the possible mechanisms by which the IL‐15Rα variant modulates light intensity physical activity. |
| Databáze: | OpenAIRE |
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