Increased number of high-affinity muscarinic receptors in rat heart after phenylhydrazine treatment
| Autor: | Patrick Robberecht, Magali Waelbroeck, Jean Christophe, Anh Nguyen Huu, Magda Claeys, Pierre Chatelain |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Agonist
Male medicine.medical_specialty endocrine system diseases medicine.drug_class Cardiomegaly Heart Rate Heart Rate -- drug effects Internal medicine Muscarinic acetylcholine receptor medicine Animals Phenylhydrazines -- pharmacology Binding site Receptor Pharmacology Chemistry Cardiomegaly -- metabolism Myocardium Thyroid Decreased Concentration Muscarinic acetylcholine receptor M2 Rats Inbred Strains Muscarinic acetylcholine receptor M1 Sciences bio-médicales et agricoles Receptors Muscarinic Phenylhydrazines Rats Endocrinology medicine.anatomical_structure Myocardium -- analysis Receptors Muscarinic -- analysis -- drug effects |
| Zdroj: | European journal of pharmacology, 91 (2-3 |
| ISSN: | 0014-2999 |
| Popis: | The effect of phenylhydrazine-induced heart hypertrophy on muscarinic cholinergic binding sites was studied in heart membranes by determining total (with [3H]NMS) and high-affinity (with [3H]Oxo-M) binding sites and estimating low-affinity binding sites by difference. Phenylhydrazine induced an increased concentration of high-affinity binding sites without affecting the concentration of low-affinity binding sites. The KD values for the ligands were unaffected. Journal Article Research Support, Non-U.S. Gov't info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|