Osteoprotegerin, Soluble Receptor Activator of Nuclear Factor-κB Ligand, and Subclinical Atherosclerosis in Children and Adolescents with Type 1 Diabetes Mellitus

Autor: Emmanouil Tsouvalas, Maria Creatsa, Andreas Alexandrou, Marina Vakaki, Irene Lambrinoudaki, George Kaparos, Paraskevi Pliatsika, Areti Augoulea, Kimon Stamatelopoulos, Kyriaki Karavanaki
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: International Journal of Endocrinology
International Journal of Endocrinology, Vol 2013 (2013)
ISSN: 1687-8345
1687-8337
Popis: Aims. To evaluate carotid intima-media thickness (cIMT) and biomarkers of the osteoprotegerin/receptor activator of nuclear factor-κB ligand (OPG/RANKL) system in type 1 diabetes (T1DM) children and adolescents and controls.Subjects and Methods. Fifty six T1DM patients (mean ± SD age: 12.0 ± 2.7 years, diabetes duration: 5.42 ± 2.87 years and HbA1c: 8.0 ± 1.5%) and 28 healthy matched controls, were studied with anthropometric and laboratory measurements, including serum OPG, soluble RANKL (sRANKL) and cIMT.Results. Anthropometric, laboratory, and cIMT measurements were similar between T1DM youngsters and controls. However patients with longer diabetes duration (>/7.0 years) had indicatively higher cIMT (cIMT = 0.49 vs 0.44 mm,P0.072) and triglyceride levels than the rest of the patients (93.7 vs 64.6 mg/dl,P0.025). Both in the total study population (β0.418,P0.027) and among T1DM patients separately (β0.604,P0.013), BMI was the only factor associated with cIMT. BMI was further associated with OPG in both groups (β−0.335,P0.003 andβ−0.356,P0.008 respectively), while sRANKL levels were not associated with any factor.Conclusions. BMI was the strongest independent predictor of cIMT among the whole population, and especially in diabetics, suggesting a possible synergistic effect of diabetes and adiposity on atherosclerotic burden. BMI was overall strongly associated with circulating OPG, but the causes of this association remain unclear.
Databáze: OpenAIRE
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