Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect
| Autor: | Daisuke Kobayashi, Takehiro Kawashiri, Shiori Shimizu, Takao Shimazoe, Nao Shigematsu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Neurite Antineoplastic Agents Pharmacology PC12 Cells Neuroprotection Rats Sprague-Dawley Mice 03 medical and health sciences 0302 clinical medicine Oral administration Cell Line Tumor health services administration mental disorders Animals Medicine Nociception assay Donepezil neoplasms business.industry lcsh:RM1-950 Peripheral Nervous System Diseases medicine.disease Sciatic Nerve digestive system diseases Rats Oxaliplatin stomatognathic diseases Neuroprotective Agents lcsh:Therapeutics. Pharmacology 030104 developmental biology Peripheral neuropathy Molecular Medicine Sciatic nerve business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 140, Iss 3, Pp 291-294 (2019) |
| ISSN: | 1347-8613 |
| DOI: | 10.1016/j.jphs.2019.05.009 |
| Popis: | Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy. Keywords: Donepezil, Oxaliplatin, Peripheral neuropathy |
| Databáze: | OpenAIRE |
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