Identification and characterization of the human type II collagen gene (COL2A1)

Autor:	Ellen Solomon, Frank Grosveld, Kathryn S.E. Cheah, Neil G. Stoker, Jane R. Griffin
Rok vydání:	1985
Předmět:	Messenger RNA Multidisciplinary Base Sequence Sequence analysis Type II collagen Clone (cell biology) Chromosome Mapping Biology Molecular biology SCN3A Genes Species Specificity Gene cluster Cosmid Animals Humans Collagen RNA Messenger Cloning Molecular Chickens Gene Research Article
Zdroj:	Proceedings of the National Academy of Sciences. 82:2555-2559
ISSN:	1091-6490 0027-8424
DOI:	10.1073/pnas.82.9.2555
Popis:	The gene contained in the human cosmid clone CosHcol1, previously designated an alpha 1(I) collagen-like gene, has now been identified. CosHcol1 hybridizes strongly to a single 5.9-kilobase mRNA species present only in tissue in which type II collagen is expressed. DNA sequence analysis shows that this clone is highly homologous to the chicken alpha 1(II) collagen gene. These data together suggest that CosHcol1 contains the human alpha 1(II) collagen gene COL2A1. The clone appears to contain the whole gene (30 kilobases in length) and will be extremely useful in the study of cartilage development and for identifying those inherited chondrodystrophies in which defects occur in this gene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d530ea5bd98761609808aac97444db3 https://doi.org/10.1073/pnas.82.9.2555 Zobrazit plný text záznamu