Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment
| Autor: | Karolina Stojowska-Swędrzyńska, Beata Furmanek-Blaszk, Dorota Kuczyńska-Wiśnik, Soroosh Monem, Ewa Laskowska, Adrianna Łupkowska |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.drug_class 030106 microbiology Antibiotics biofilm Catalysis Microbiology lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences Antibiotic resistance Immune system multidrug resistance medicine Physical and Theoretical Chemistry persisters lcsh:QH301-705.5 Molecular Biology Pathogen Spectroscopy proteostasis biology Host (biology) Organic Chemistry Biofilm Acinetobacter baumannii General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Computer Science Applications Multiple drug resistance 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 desiccation stress bacteria |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 5498, p 5498 (2020) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21155498 |
| Popis: | Acinetobacter baumannii is considered one of the most persistent pathogens responsible for nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high morbidity and mortality caused by this pathogen, A. baumannii was placed on the World Health Organization (WHO) drug-resistant bacteria and antimicrobial resistance research priority list. This review summarizes current studies on mechanisms that protect A. baumannii against multiple stresses caused by the host immune response, outside host environment, and antibiotic treatment. We particularly focus on the ability of A. baumannii to survive long-term desiccation on abiotic surfaces and the population heterogeneity in A. baumannii biofilms. Insight into these protective mechanisms may provide clues for the development of new strategies to fight multidrug resistant strains of A. baumannii. |
| Databáze: | OpenAIRE |
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