Septicaemia is associated with increased disease activity and mortality in systemic lupus erythematosus: a retrospective analysis from Taiwan

Autor:	P H Tsai, S S Jang, L B Liou
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Adolescent Taiwan Comorbidity Disease Severity of Illness Index Disease activity Young Adult Rheumatology Sepsis Internal medicine otorhinolaryngologic diseases medicine Retrospective analysis Humans Lupus Erythematosus Systemic Child skin and connective tissue diseases Aged Retrospective Studies Aged 80 and over business.industry Systemic lupus Middle Aged bacterial infections and mycoses Hospitalization Logistic Models Child Preschool Female business
Zdroj:	Lupus. 29:191-198
ISSN:	1477-0962 0961-2033
Popis:	Objective This study aimed to investigate how septicaemia, non-septicaemia infection and the disease itself are associated with disease activity and mortality in inpatients with systemic lupus erythematosus (SLE) in Taiwan. Methods We retrospectively reviewed 1115 patients and enrolled 427 with SLE admitted for lupus flare-ups and co-morbidities. Disease activity and infection type/site were recorded and categorized according to the causes of admission and mortality into three categories, of which two were specified as follows: (a) septicaemia admissions, non-septicaemia admissions; and (b) septicaemia mortality, non-septicaemia infection mortality and non-infection mortality. The relationships between lupus flare-ups and mortality in different groups were analysed using an unpaired t-test, Mann–Whitney U-test and logistic regression. Results Septicaemia was the major cause of mortality in SLE inpatients. There were 98 (22.95%) mortality patients among all 427 SLE patients. The septicaemia admissions had higher disease activity (SLE Disease Activity Index 2000 = 13.00 ± 7.98) than the non-septicaemia admissions (9.77 ± 5.72; p Conclusion Septicaemia relates to increased lupus disease activity and is associated with a greater risk of mortality in the SLE patients than other causes of admission. Fewer previous septicaemia admissions decrease the risk of septicaemia mortality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d513af415b99911c9c3ad4354379599 https://doi.org/10.1177/0961203319899162 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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