| Autor: |
Russell, Holly, Kedzierska, Katarzyna, Buchanan, Daniel D., Thomas, Rachael, Tham, Emma, Mints, Miriam, Keränen, Anne, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tomlinson, Ian, Church, David, Spurdle, Amanda B., O’Mara, Tracy A., Lewis, Annabelle |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.12629428.v1 |
| Popis: |
Additional file 1: Supplementary figure 1. A Boxplot of the proportion of methylation proximal to the MLH1 promoter and MLH1 gene expression in EC patient samples (TCGA-UCEC) stratified by rs1800734 genotype and MSI with high MLH1 methylation (median Beta >0.2) and MSS status. Supplementary figure 2: MLH1 expression of MSI samples inversely correlates with promoter methylation. Supplementary figure 3: In HEC1A cells TFAP4 binds preferentially to the rs1800734 G allele. Supplementary table 1: Sample numbers and minor allele frequency for rs1800734 for each data set. Supplementary table 4: Statistical test p-values on genotype vs methylation and genotype vs expression associations in TCGA-UEAC sample subsets. Supplementary table 5: Primers used for genotyping, amplicon bisulphite sequencing and cDNA amplification. Supplementary table 6: Primers used for Q-PCR (SYBR) amplification of ChIP DNA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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