Hunt for the Hidden Trait
| Autor: | Nandini Singh, Vanamala Alwar, Reeti Kavdia, Karuna Rameshkumar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Sickle cell trait congenital hereditary and neonatal diseases and abnormalities Hemoglobin electrophoresis peripheral smear medicine.diagnostic_test Mean corpuscular hemoglobin concentration business.industry Thalassemia Microcytosis lcsh:R Mean corpuscular hemoglobin lcsh:Medicine medicine.disease Gastroenterology Iron-deficiency anemia Internal medicine hemic and lymphatic diseases Iron deficiency anemia medicine Original Article business Mean corpuscular volume Thalassemia trait |
| Zdroj: | Journal of Laboratory Physicians Journal of Laboratory Physicians, Vol 1, Iss 01, Pp 015-018 (2009) |
| ISSN: | 0974-7826 0974-2727 |
| Popis: | Objective: To assess the efficacy of a peripheral smear examination as a screening tool for β-thalassemia trait. Materials and Methods: 17 623 Leishman-stained peripheral smears were evaluated during the period from July 2006 to September 2007. The following parameters were studied: hemoglobin, red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and red cell distribution width. All the cases that showed microcytosis, hypochromia, erythrocytosis and absence of anisopoikilocytosis were suspected of having the thalassemia trait (TT), and all these cases were further evaluated with Alkaline Hemoglobin Electrophoresis for confirmation. Results: Of the 17 623 smears examined, 60 cases were considered suspicious of having TT. Alkaline hemoglobin electrophoresis carried out on all these cases revealed an elevated HbA 2 (Mean = 7.5%). Five cases evaluated were found to have other hemoglobinopathies (1 Sickle cell trait, 3 Hb-E, 1 thalassemia intermedia). Conclusion: Careful screening of peripheral smear is an invaluable screening tool for thalassemia trait (PPV - 95%). There must be awareness among the peripheral centers about the importance of peripheral smear screening and the affected persons should be counseled. |
| Databáze: | OpenAIRE |
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