Stem Cells in Cardiovascular Medicine: Historical Overview and Future Prospects
| Autor: | Mostafa Samak, Rabea Hinkel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Induced Pluripotent Stem Cells Cell- and Tissue-Based Therapy ESC Disease Review 030204 cardiovascular system & hematology Bioinformatics Cell Line 03 medical and health sciences Mice 0302 clinical medicine PSC cardiovascular disease Medicine Animals Humans Myocytes Cardiac Induced pluripotent stem cell Embryonic Stem Cells Cause of death iPSC business.industry Regeneration (biology) Heart General Medicine medicine.disease Embryonic stem cell Review article 030104 developmental biology Cardiovascular Diseases Heart failure regeneration Stem cell business |
| Zdroj: | Cells |
| ISSN: | 2073-4409 |
| Popis: | Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a low regenerative capacity, leading to a loss of cardiomyocytes and persistent tissue scaring, which entails a morbid pathologic sequela. Novel therapeutic approaches are urgently needed. Stem cells, such as induced pluripotent stem cells or embryonic stem cells, exhibit great potential for cell-replacement therapy and an excellent tool for disease modeling, as well as pharmaceutical screening of novel drugs and their cardiac side effects. This review article covers not only the origin of stem cells but tries to summarize their translational potential, as well as potential risks and clinical translation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |