Revisiting the matricellular concept
| Autor: | E. Helene Sage, Joanne E. Murphy-Ullrich |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Matricellular
Tenascins Context (language use) Computational biology Biology Bioinformatics Models Biological Regenerative medicine Article CCN Intercellular Signaling Proteins Thrombospondin 1 Translational Research Biomedical Mice 03 medical and health sciences 0302 clinical medicine Animals Humans Osteonectin Thrombospondins Molecular Biology 030304 developmental biology Extracellular Matrix Proteins Hevin CCN 0303 health sciences Tissue Engineering integumentary system R-spondin Alternative splicing Matricellular protein Cell adhesion SPARC Extracellular matrix 3. Good health Fibulin CTGF Alternative Splicing Receptors Antigen Periostin Gene Expression Regulation 030220 oncology & carcinogenesis Osteopontin Protein Processing Post-Translational Biomarkers |
| Zdroj: | Matrix biology : journal of the International Society for Matrix Biology |
| ISSN: | 0945-053X |
| Popis: | The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s to account for the non-lethal phenotypes of mice with inactivated genes encoding thrombospondin-1, tenascin-C, or SPARC. It was also recognized that these extracellular matrix proteins were primarily counter or de-adhesive. This review reappraises the matricellular concept after nearly two decades of continuous investigation. The expanded matricellular family as well as the diverse and often unexpected functions, cellular location, and interacting partners/receptors of matricellular proteins are considered. Development of therapeutic strategies that target matricellular proteins are discussed in the context of pathology and regenerative medicine. |
| Databáze: | OpenAIRE |
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